Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Epigenome-based cancer risk prediction: rationale, opportunities and challengesEpigenome-based cancer risk prediction: rationale, opportunities and challenges, Published online: 27 February 2018; doi:10.1038/nrclinonc.2018.30The development of cancer involves several epigenomic alterations, and the presence of certain alterations before the development of cancer is associated with cancer risk. In this Review, the authors describe the potential of epigenomics-based assays to predict an individual's risk of cancer, including discussions of technical, practical and societal issues regarding the implementation of such assays.

Source: Nature Clinical Practice Oncology - February 27, 2018 Category: Cancer & Oncology Authors: Martin Widschwendter Allison Jones Iona Evans Daniel Reisel Joakim Dillner Karin Sundstr öm Ewout W. Steyerberg Yvonne Vergouwe Odette Wegwarth Felix G. Rebitschek Uwe Siebert Gaby Sroczynski Inez D. de Beaufort Ineke Bolt David Cibula Michal Zikan Line Source Type: research