In vitro evaluation of a simulated pneumoperitoneum environment using carbon dioxide on canine transitional cell carcinoma

Conclusion/Clinical significance: A positive pressure CO2 environment significantly decreased the viability of TCC and MDCK cells under specific conditions without influencing their proliferation up to 7 days postexposure. Investigating these effects in clinical patients undergoing CO2 laparoscopy is essential to assess for port site metastasis or peritoneal carcinomatosis in order to translate these in vitro results to clinical recommendations.

Source: Veterinary Surgery - February 1, 2018 Category: Veterinary Research Authors: Rashi Asthana, Michelle L. Oblak, Ameet Singh, Anthony J. Mutsaers Tags: ORIGINAL ARTICLE Source Type: research