The presence of tumor extrachomosomal circular DNA (ecDNA) as a component of liquid biopsy in blood

In molecular biology covalently closed circular DNAsare able to passthrough double layer of eukaryotic cellular membrane. Very recently the presence of circular extra chromosomal DNA (ecDNA) has been shown which are different in seventeen different types of cancers. In fact, ecDNA are the tricky way of oncogenes to increase their copy number. We hypothesis the presence of ecDNA in the blood of cancer patients as a subpopulation of liquid biopsy. On the occasion of their presence in blood they will be very beneficial to cover the small amount of cell frees DNA (cfDNA).
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research