Role of Apolipoprotein E in the tangled mystery of pain

Pain is one of the common and debilitating manifestations associated with the majority of diseased conditions, making it a serious health concern worldwide. While trying to decipher the cryptic mechanism of pain in hope to provide better gene-based therapeutics, researchers have concluded pain to be of multigenic origin.Apolipoprotein E is a protein coded by APOE gene containing 4 exons, located on chromosome 19q13.2. It is among the key regulators of various crucial body functions such as lipid transport, apoptosis, vitamin k pathway, and cognition, hence, it is highly suspected to play a pivotal role in the nociception process.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research