The α2 isoform Na,K‐ATPase modulates contraction of rat mesenteric small artery via cSrc–dependent Ca2+ sensitization

ConclusionsData suggest that micromolar ouabain potentiates agonist‐induced contraction of rat mesenteric small artery via Na,K‐ATPase dependent cSrc activation, which increases Ca2+ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation. This mechanism may be critical for acute control of vascular tone.

Source: Acta Physiologica - February 26, 2018 Category: Physiology Authors: Elena V. Bouzinova, Lise Hangaard, Christian Staehr, Aleksandra Mazur, Avelino Ferreira, Alexander Chibalin, Shaun L. Sandow, Zijian Xie, Christian Aalkjaer, Vladimir V. Matchkov Tags: Regular Paper Source Type: research