The monoamine stabilizer ( −)‐OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats

In conclusion, our results provide further support for OSU6162 as a novel treatment for alcohol use disorder. The results further indicate that improvement of motor impulse control might be one mechanism behind OSU6162's ability to attenuate alcohol‐mediated behaviors. A main problem in the treatment of alcohol use disorder (AUD) is the long‐lasting vulnerability to relapse. Impaired impulse control, often seen in AUD individuals, contribute to relapse to alcohol drinking. Here, we showed that the monoamine stabilizer OSU6162 improved motor impulsivity (i.e. decreased premature responses) in both alcohol‐naive and alcohol drinking rats as measured with the five‐choice serial reaction time task. These results provide further support for the potential of OSU6162 as a novel medication for AUD.
Source: Addiction Biology - Category: Addiction Authors: Tags: Original Article Source Type: research