Prognostic roles of L1-cell adhesion molecule up-regulation in association with p53 overexpression and E-cadherin down-regulation in endometrial carcinoma patients

Background The recent guidelines for endometrial carcinoma (EC) management classify patients into low-risk, intermediate-risk, high-to-intermediate risk, and high-risk groups. A few patients in the category of low-risk disease have been found to have relapse of the tumor; this has not been explained to date. Moreover, it is essential to assess the prognosis of other risk groups of EC. Also, the identification of patients for whom the adjuvant therapy will be more beneficial than other patients who will not require additional management after surgery is an essential aim of the recent researches on EC. Thus, recent studies have focused on the detection of prognostic biomarkers that might improve risk stratification and identify which patients will need neoadjuvant chemotherapy after surgery. L1-cell adhesion molecule (L1CAM) is a membrane glycoprotein member of the immunoglobulin superfamily. P53 is a nuclear transcription factor and was found to be an established tumor suppressor. E-cadherin is an integral cell adhesion molecule and it is a component of the adherens junction. The aim of our study is to investigate the prognostic significance of L1CAM, p53, and E-cadherin expression in early-stage, low-risk, intermediate-risk, and high-risk EC, and correlate their expression with clinicopathological criteria, tumor progression, recurrence, risk stratification of EC patients, and identification of patients who will require neoadjuvant chemotherapy after surgery. Patients and...
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research