The impact of lymphocytic infiltrates on the progression of benign prostatic hyperplasia to prostatic carcinoma

Background and objective Although lymphocytic infiltrate (LI) has been reported in benign prostatic hyperplasia (BPH) and prostate carcinoma (PC), its role in BPH progression to PC is still a topic of debate. The aim of this study is to investigate the role of LI in PC progression through correlation of LI to expression of nuclear factor κB (NF-κB) and cyclin D1 aiming to find a new diagnostic marker, or a potential therapeutic target that may improve PC management. Materials and methods We studied 100 BPH cases and 50% of these cases also had PC. Archived paraffin blocks were microtomed at 4–5 μm and stained with hematoxylin and eosin to revise diagnosis and grading. In addition, an immunohistochemical analysis was carried out using antibodies against CD3, CD20, NF-κB, and cyclin D1 and then these results were correlated with clinicopathological variables. Results We found LI in both BPH and PC cases, with a predominance of T lymphocytes over B lymphocytes. There was a statistically significant correlation of LI to NF-κB (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research