Meropenem Time Above the MIC Exposure is Predictive of Response in Cystic Fibrosis Children with Acute Pulmonary Exacerbations

Meropenem exposures from 15 children (8-17 years old) with cystic fibrosis (CF) acute pulmonary exacerbation were analyzed to define the pharmacodynamic threshold required for a positive response. The primary endpoint was the relative increase in forced expiratory volume in 1 second ( ↑FEV1) between pre- and post-treatment. Meropenem pharmacodynamic indices (fT>MIC, fAUC/MIC, fCmin/MIC) over the first 24 hours were estimated for each participant based on their individual parameter estimates and the isolated pathogen with the highest meropenem MIC.

Source: Diagnostic Microbiology and Infectious Disease - February 24, 2018 Category: Microbiology Authors: Joseph L. Kuti, Rebecca S. Pettit, Natalie Neu, Jeffrey J. Cies, Craig Lapin, Marianne S. Muhlebach, Kimberly J. Novak, Sean T. Nguyen, Lisa Saiman, David P. Nicolau Source Type: research