Hepatitis C virus direct ‐acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties

ConclusionsEnrichment of immunomodulatory microRNAs in exosomes of HCV patients was correlated with their inhibitory activity on innate immune cells function. Direct‐acting antivirals (DAA) treatment was observed to revert both microRNA content and functional profiles of systemic exosomes towards those of healthy donors. Exosome‐associated microRNAs may provide valuable biomarkers to monitor immune response recovery.

Source: Liver International - February 24, 2018 Category: Gastroenterology Authors: Laura Santangelo, Veronica Bordoni, Claudia Montaldo, Eleonora Cimini, Alessandra Zingoni, Cecilia Battistelli, Gianpiero D'Offizi, Maria R. Capobianchi, Angela Santoni, Marco Tripodi, Chiara Agrati Tags: ORIGINAL ARTICLE Source Type: research