The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers

Chromatin remodelling is one of the mechanisms essential in dynamic regulation of gene expression. In mammalians, this is performed by a number of different proteins/protein complexes (Muchardt and Yaniv, 1999). SWI/SNF is one of these complexes that was first identified in yeast when genes affecting the SWItch in mating type (Haber and Garvik, 1977) and Sucrose Non-Fermenting (SNF) phenotypes were identified (Neigeborn and Carlson, 1984).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research