PVDF piezoelectric neural conduit incorporated pre-differentiated adipose-derived stem cells may accelerate the repair of peripheral nerve injury

Peripheral nerve injury is a common trauma disease which often results in sensory and motor dysfunction. However, the surgical repair for peripheral nerve injury, especially for large segmental defects, is not satisfactory. Growing evidences suggest that artificial neural conduit combined with stem cells is potential tissue engineering remediation method for peripheral nerve injury. But, selections of biomaterials and stem cells are still being debated. Based on the findings from previous studies, we hypothesize that PVDF piezoelectric neural conduit incorporated Schwann-like cells which pre-differentiated from adipose-derived stem cells may substantially promote the repair of peripheral nerve injury.

Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: Li Ming, Zhang Peixun, Zhang Dianying Source Type: research