[Correspondence] Xpert Ultra's place in the diagnosis of tuberculous meningitis – Authors' reply

In response to our study on the performance of GeneXpert MTB/RIF Ultra (Xpert Ultra) for diagnosis of tuberculous meningitis,1 Sarman Singh and Mani M Sankar reported their experience using low volumes of cerebrospinal fluid (CSF) for diagnosis of tuberculous meningitis.2 Additionally, Tom Boyles discusses his group's previous work on thresholds of disease likelihood above which treatment should be started for tuberculous meningitis and adapted it to Xpert Ultra using our data. Boyles reports that Xpert Ultra is likely to be more useful in ruling out tuberculous meningitis in a broader range of patients than was the original GeneXpert MTB/RIF (Xpert).

Source: The Lancet Infectious Diseases - February 22, 2018 Category: Infectious Diseases Authors: Nathan C Bahr, David R Boulware, Fiona V Cresswell Tags: Correspondence Source Type: research