[Comment] Doxycycline post-exposure prophylaxis: let the debate begin

Should physicians prescribe doxycycline to prevent syphilis? In their study published in The Lancet Infectious Diseases, Jean-Michel Molina and colleagues1 report on the findings of the first large, open-label randomised control trial to help answer this question.2 Their findings show that, among men who have sex with men (MSM) who were using pre-exposure prophylaxis (PrEP) for HIV and who had a median of ten partners every 2 months, taking doxycycline within 24 h after sex reduced the incidence of chlamydia by 70% when compared with no prophylaxis (hazard ratio [HR] 0 ·30, 95% CI 0·13–0·70; p=0·006); similar results were observed for syphilis (0·27, 0·07–0·98; p=0·047), but not for gonorrhoea (0·83, 0·47–1·47; p=0·52).
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research