Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes

ConclusionGene expression analysis of synovial tissue revealed three distinct synovial subtypes. We used these labels to generate a histology scoring algorithm that associates with levels of ESR, CRP and autoantibodies. Comparison of gene expression patterns to clinical features revealed a potentially clinically important distinction: mechanisms of pain may differ in patients with different synovial subtypes.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - February 1, 2018 Category: Rheumatology Authors: Dana E. Orange, Phaedra Agius, Edward F. DiCarlo, Nicolas Robine, Heather Geiger, Jackie Szymonifka, Michael McNamara, Ryan Cummings, Kathleen M. Andersen, Serene Mirza, Mark Figgie, Lionel Ivashkiv, Alessandra B. Pernis, Caroline Jiang, Mayu Frank, Rober Tags: Full Length Source Type: research