Targeting B cell receptor signalling in cancer: preclinical and clinical advances

Nature Reviews Cancer 18, 148 (2018).
doi:10.1038/nrc.2017.121

Authors: Jan A. Burger & Adrian Wiestner
B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive immunity. BCR signalling also supports the survival and growth of malignant B cells in patients with B cell leukaemias or lymphomas. The mechanism of BCR pathway activation in these diseases includes

Source: Nature Reviews Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Jan A. Burger Adrian Wiestner Tags: Review Source Type: research