Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation

Human herpesvirus-6B (HHV-6B) is a T cell tropic virus which belongs to the betaherpesvirus subfamily. Human herpesvirus-6A (HHV-6A) and HHV-6B were classified by International Committee on Taxonomy of Viruses as distinct species according to genetic and antigenic differences and cell tropism [1 –5]. While the pathogenesis of HHV-6A is still unknown, HHV-6B is the causative agent for exanthem subitum [6] and the virus remains latent after primary infection. In an immunocompromised host, such as a patient after allogeneic hematopoietic stem cell transplantation (allo-HSCT), HHV-6B can reac tivate and occasionally causes encephalitis [7,8].

Source: Journal of Clinical Virology - February 20, 2018 Category: Virology Authors: Satoshi Nagamata, Miwako Nagasaka, Akiko Kawabata, Kenji Kishimoto, Daiichiro Hasegawa, Yoshiyuki Kosaka, Takeshi Mori, Ichiro Morioka, Noriyuki Nishimura, Kazumoto Iijima, Hideto Yamada, Shinichiro Kawamoto, Kimikazu Yakushijin, Hiroshi Matsuoka, Yasuko Source Type: research