Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy

In this study, serum levels of ALCAM were elevated in food allergy‐induced WT mice and children with food allergy. Moreover, immune responses and T cell activation were attenuated in OVA‐challenged ALCAM–/– mice. These results indicate that ALCAM regulates food allergy by affecting T cell activation. The number of CD3+CD4+ T cells was enhanced throughout the immune tissues, especially in the small intestine, of OVA‐challenged WT mice when compared to the numbers of T cells in control WT mice. However, the number of CD3+CD4+ T cells was lower in OVA‐challenged ALCAM‐/‐ mice than in OVA‐challenged WT mice. We also found that the number of activated cells (CD4+CD44highCD62Llow) decreased in OVA‐challenged ALCAM‐/‐ mice than in OVA‐challenged WT mice.
Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research