Could ryanodine receptor dysfunction be linked to PKR brain accumulations in Alzheimer ’s disease?

The dysfunction of ryanodine receptor (RyR) in Alzheimer ’s disease (AD) has been underlined previously and is part of the Calcium hypothesis at the origin of some abnormal cellular metabolisms leading to AD brains lesions. A recent report has contributed to this hypothesis [1]. They have demonstrated that endoplasmic reticulum (ER) calcium leak could r esult in calcium dependent abnormal signaling pathways participating in AD abnormal lesions. They nicely show that calcium accumulation could result in calpain and CaMKK2 activation contributing to Aβ production and tau phosphorylation.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research