Prevalence of orofacial clefts and risks for nonsyndromic cleft lip with or without cleft palate in newborns at a university hospital from West Mexico

ABSTRACT We determined the overall prevalence of typical orofacial clefts (OFCs) and the potential risks for nonsyndromic cleft lip with or without palate (NSCL±P) in a University Hospital from west México. For the prevalence, 227 live born infants with typical OFCs were included from a total of 81,193 births occurred during the period 2009 to 2016 at the ‘Dr. Juan I. Menchaca’ Civil Hospital of Guadalajara (Guadalajara, Jalisco, Mexico). To evaluate potential risks, a case‐control study was conducted among 420 newborns, including only those 105 patients with NSCL±P (cases), and 315 infants without birth defects (controls). Data were analyzed using multivariable logistic regression analysis expressed as adjusted odds ratio (aORs) with 95% confidence intervals (95% CI). The overall prevalence for typical OFCs was 28 per 10,000 (95% CI 24.3‐31.6), or 1 per 358 live births. The mean values for the pre‐pregnancy weight, ante‐partum weight, and pre‐pregnancy body mass index were statistically higher among the mothers of cases. Infants with NSCL±P had a significantly higher risk for previous history of any type of congenital anomaly (aOR 2.7; 95% CI 1.4‐5.1), history of a relative with CL±P (aOR 19.6; 95% CI 8.2‐47.1), and first‐trimester exposures to progestogens (aOR 6.8; 95% CI 1.8‐25.3), hyperthermia (aOR 3.4; 95% CI 1.1‐10.6), and common cold (aOR 3.6; 95% CI 1.1‐11.9). These risks could have contributed to explain the high prevalence of OFCs in ...
Source: Congenital Anomalies - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research