Analysis of 13C and 14C labeling in pyruvate and lactate in tumor and blood of lymphoma ‐bearing mice injected with 13C‐ and 14C‐labeled pyruvate

This study shows that measurements of hyperpolarized 13C label exchange between pyruvate and lactate in a murine tumor model can provide an estimate of the true isotope flux if the concentration of labeled pyruvate that reaches the tumor can be determined.

Metabolic imaging with hyperpolarized [1‐13C]pyruvate has shown great promise in preclinical and clinical studies. This study shows, in a murine tumor model, that only a small fraction of the injected hyperpolarized [1‐13C]pyruvate reaches the tumor and that measurements of hyperpolarized 13C label exchange between pyruvate and lactate can provide a true estimate of the isotope flux if the concentration of labeled pyruvate that reaches the tumor can be determined.

Source: NMR in Biomedicine - February 19, 2018 Category: Radiology Authors: E.M. Serrao, M.I. Kettunen, T.B. Rodrigues, D.Y. Lewis, F.A. Gallagher, D.E. Hu, K.M. Brindle Tags: RESEARCH ARTICLE Source Type: research