Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder

In conclusion, the underlying studies of this review provide evidence that allopregnanolone is the provoking factor behind the negative mood symptoms in PMDD and that isoallopregnanolone could ameliorate the symptoms as a result of its ability to antagonise the allopregnanolone effect on the GABAA receptor.

Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: M. Bixo, M. Johansson, E. Timby, L. Michalski, T. B äckström Tags: REVIEW ARTICLE Source Type: research