Prognostic implications of low transferrin saturation in patients with primary myelofibrosis

Philadelphia chromosome negative myeloproliferative neoplasms (Ph- MPNs) [1] are malignant diseases developing from clonally transformed hematopoietic stem cell [2]. They have classically been divided into primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocytosis (ET). A majority of Ph- MPN patients bear a mutation in either of Janus-kinase-2 (JAK2), Calreticulin (CALR) or Myeloproliferative-leukemia-virus-oncogene (MPL) genes [3] resulting in constitutive activation of JAK/signal-transducer-and-activator-of-transcription (STAT) signaling pathway, strong myeloproliferation and high inflammatory atmosphere characteristic for these diseases [4].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research