High frequency of intermediate and poor risk copy number abnormalities in pediatric cohort of B-ALL correlate with high MRD post induction

B-cell precursor acute lymphoblastic leukemia (B-ALL) comprises 80 –85% of all acute lymphoblastic leukemia and is the most common type of childhood leukemia. Age, white blood cell (WBC) count at presentation, minimal residual disease (MRD) post induction and chromosomal translocations are well known prognostic and risk stratification markers in B-ALL. Most devel oped countries show event free survival (EFS) from 74% to 87% and overall survival (OS) from 85% to 90% [1], while a recently published study from our country shows EFS and OS to be only 66% and 74%, respectively [2].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research