Diminished CXCR5 expression in peripheral blood of patients with Sj ögren's syndrome may relate to both genotype and salivary gland homing

In conclusion, we link a genetic susceptibility allele for SS to a functional phenotype in terms of decreased CXCR5 expression. The decrease of CXCR5+ cells in circulation was also related to homing of B and T cells to the autoimmune target organ. Therapeutic drugs targeting the CXCR5/CXCL13 axis may be useful in SS. This article is protected by copyright. All rights reserved.

Source: Clinical and Experimental Immunology - February 17, 2018 Category: Allergy & Immunology Authors: Lara A. Aqrawi, Margarita Ivanchenko, Albin Bj örk, Jorge I. Ramírez Sepúlveda, Juliana Imgenberg‐Kreuz, Marika Kvarnström, Philipp Haselmayer, Janicke Liaaen Jensen, Gunnel Nordmark, Karine Chemin, Kathrine Skarstein, Marie Wahren‐Herlenius Tags: Original Article Source Type: research