Load-Independent Systolic and Diastolic Right Ventricular Function in Heart Failure With Preserved Ejection Fraction as Assessed by Resting and Handgrip Exercise Pressure-Volume Loops [Original Articles]

Conclusions:
In compensated stages of the HFpEF syndrome, systolic RV function is preserved, but diastolic abnormalities with intrinsic RV stiffness and prolonged RV relaxation are already present. Impaired diastolic RV reserve contributes to a blunted increase in cardiac output during exertion. Because impairments in diastolic function seem to be a biventricular phenomenon, RV diastolic dysfunction warrants further consideration when characterizing HFpEF patients.

Clinical Trial Registration:
https://www.clinicaltrials.gov. Unique identifier: NCT02459626.

Source: Circulation: Heart Failure - February 15, 2018 Category: Cardiology Authors: Rommel, K.-P., von Roeder, M., Oberueck, C., Latuscynski, K., Besler, C., Blazek, S., Stiermaier, T., Fengler, K., Adams, V., Sandri, M., Linke, A., Schuler, G., Thiele, H., Lurz, P. Tags: Heart Failure Original Articles Source Type: research