Cell type specific tracing of the subcortical input to primary visual cortex from the basal forebrain

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The basal forebrain provides a modulatory cholinergic input to cerebral cortex through volume transmission which allows access to receptors throughout all cortical layers. Direct synaptic inputs are also present in deep layers. The paper used a dual viral retrograde tracing technique to show that basal forebrain inputs synapse directly onto inhibitory, but not excitatory neurons in primary visual cortex (V1), suggesting a more immediate modulatory role on local inhibition.

Source: The Journal of Comparative Neurology - February 14, 2018 Category: Neurology Authors: Georgina A. Lean, Yong ‐jun Liu, David C. Lyon Tags: Research Article Source Type: research