bis ‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM)—the active metabolite of the laxatives bisacodyl and sodium picosulfate—enhances contractility and secretion in human intestine in vitro

Conclusions and InterferencesBHPM enhanced mucosal secretion and muscle contractility. Results suggested that the laxative effect of BHPM was a consequence of the increase in muscle tone as well as an increased K+ secretion when acting luminally and a nerve‐driven Cl− and HCO3− secretion once acting basolaterally after absorption. We identified the action of bis‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM), the active metabolite of the laxatives bisacodyl and sodium picosulfate, in human intestinal samples. BHPM increased muscle tone in small and large intestine. It enhanced K+ secretion when acting luminally and nerve‐driven Cl− and HCO3− secretion once acting basolaterally after absorption. Increase in muscle activity and epithelial secretion explain the laxative effects of BHPM.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnmo.13311

Source: Neurogastroenterology and Motility - February 14, 2018 Category: Gastroenterology Authors: D. Krueger, I. E. Demir, G. O. Ceyhan, F. Zeller, M. Schemann Tags: ORIGINAL ARTICLE Source Type: research