Augmented Th17 Differentiation Leads to Cutaneous and Synovio ‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

ConclusionPerturbation of the IL‐23/Th17 axis instigates Th17‐mediated inflammation in R26STAT3Cstopfl/fl CD4Cre mice, leading to cutaneous and synovio‐entheseal inflammation, and bone pathology highly reminiscent of psoriatic arthritis. Both IL‐17A and IL‐22 produced by Th17 cells play critical roles in promoting the cutaneous and musculoskeletal inflammation that characterizes psoriatic arthritis..This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - February 13, 2018 Category: Rheumatology Authors: Lu Yang, Melania H. Fanok, Aranzazu Mediero ‐Munoz, Laura K Fogli, Carmen Corciulo, Shahla Abdollahi, Bruce N. Cronstein, Jose U. Scher, Sergei B. Koralov Tags: Full Length Source Type: research