[Comment] The evolving landscape of epilepsy neuropathology

The neuropathological findings from brain tissue specimens taken from 9523 adults and children with treatment-resistant focal epilepsy who had resective surgery were recently published in the New England Journal of Medicine.1 These specimens were taken from a collaborative brain tissue registry involving 27 European centres, which is possibly the largest database of surgically resected neuropathology in epilepsy compiled to date. The most common pathologies were hippocampal sclerosis (36%), developmental tumours (gangliogliomas and dysembryonic neuroepithelial tumours, 16%), focal cortical dysplasias (14%), cavernous angioma (4 ·5%), and glial scars (4·8%); in around 8% of the specimens no pathology was found.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research