[Comment] Capturing the Alzheimer's disease pathological cascade

Alzheimer's disease is thought to begin insidiously, when amyloid β (Aβ) aggregates into plaques in the brain while cognition is still unimpaired. After Aβ aggregation has started, it can take up to 20 years for full-blown dementia to manifest.1,2 What happens during this period is uncertain, as long-term follow-up studies have not yet been completed. Current d isease development models are based mostly on cross-sectional studies in people without dementia who have aggregated Aβ, as assessed indirectly by biomarkers in CSF or by PET scanning.

Source: Lancet Neurology - January 31, 2018 Category: Neurology Authors: Betty M Tijms, Pieter Jelle Visser Tags: Comment Source Type: research