[Comment] DBS for Parkinson's disease with behavioural disturbances

Behavioural problems —eg, impulse control disorders, excessive and uncontrollable intake of levodopa, punding, restlessness, and disarray behaviour—are common in patients with Parkinson's disease and frequently represent a challenge for clinical management.1 Behavioural complications are associated directly with med ications for Parkinson's disease (particularly dopamine agonists) and typically arise after prolonged exposure to such drugs, leading to a functional hyperdopaminergic state. Disease-related structural features of the brain (eg, the pattern of nigrostriatal dopaminergic denervation) and individual p redisposing factors (eg, male sex, young age at onset) are also determinants of behavioural complications.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research