Alanine and glycine conjugates of [18F](2S,4R)4-fluoroglutamine for tumor imaging

Glutamine is an essential source of energy, metabolic substrates, and building block for supporting tumor proliferation. Previously, [18F](2S,4R)4-fluoroglutamine (4F –Gln) was reported as a glutamine-related metabolic imaging agent. To improve the in vivo kinetics of this radiotracer, two new dipeptides, [18F]Gly-(2S,4R)4-fluoroglutamine (Gly-4F-Gln) and [18F]Ala-(2S,4R)4-fluoroglutamine (Ala-4F-Gln) were investigated.

Source: Nuclear Medicine and Biology - February 13, 2018 Category: Nuclear Medicine Authors: Zhihao Zha, Karl Ploessl, Brian P. Lieberman, Limin Wang, Hank F. Kung Source Type: research