Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with  inhibitors—A retrospective analysis

ConclusionsRecombinant factor VIII Fc fusion protein demonstrated rapid time to tolerization in high‐risk first‐time ITI patients. For rescue ITI, rFVIIIFc showed therapeutic benefit in some patients who previously failed ITI with other products. These findings highlight the need to further evaluate the use of rFVIIIFc for ITI.

Source: Haemophilia - February 13, 2018 Category: Hematology Authors: M. Carcao, A. Shapiro, J. M. Staber, N. Hwang, C. Druzgal, K. Lieuw, M. Belletrutti, C. D. Thornburg, S. P. Ahuja, J. Morales ‐Arias, J. Dumont, G. Miyasato, E. Tsao, N. Jain, S. W. Pipe Tags: ORIGINAL ARTICLE Source Type: research