Transcriptomic definition of molecular subgroups of small round cell sarcomas

This study also refined the characteristics of some entities such as EWSR1‐PATZ1 spindle cell sarcoma or FUS‐NFATC2 bone tumours that are different from EWSR1‐NFATC2 tumours and transcriptionally resemble CIC‐fused tumour entities. We also describe a completely novel group of epithelioid and spindle‐cell rhabdomyosarcomas characterized by EWSR1‐ or FUS‐TFCP2 fusions. Finally, expression data identified some potentially new therapeutic targets or pathways.

Source: The Journal of Pathology - February 12, 2018 Category: Pathology Authors: Sarah Watson, Virginie Perrin, Delphine Guillemot, Stephanie Reynaud, Jean ‐Michel Coindre, Marie Karanian, Jean‐Marc Guinebretière, Paul Freneaux, François Le Loarer, Megane Bouvet, Louise Galmiche‐Rolland, Frédérique Larousserie, Elisabeth Lon Tags: Original Paper Source Type: research