Burst Spinal Cord Stimulation: Review of Preclinical Studies and Comments on Clinical Outcomes
ConclusionsBurst stimulation offers a novel pain reduction tool with the absence of uncomfortable paresthesia for failed back surgery syndrome, diabetic neuropathic pain, and anesthesia dolorosa. Preclinical models have emphasized that the potential mechanisms for burst therapy could be related to neural coding algorithms that mimic the natural nervous system firing patterns, resulting in effects on both the medial and lateral pain pathways. Other mechanisms include frequency dependent opioid release, modulation of the pain gate, and activation of electrical and chemical synapses.
Source: Neuromodulation - Category: Neurology Authors: Krishnan Chakravarthy, Alexander R. Kent, Adil Raza, Fang Xing, Thomas M. Kinfe Tags: Review Article Source Type: research
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