Cyclosporine A induces endothelin ‐converting enzyme‐1: Studies in vivo and in vitro

ConclusionCsA induces ECE‐1 via both hypoxic and non‐hypoxic pathways. ECE‐1 may contribute to increased renal ET‐1 generation following CsA, participating in a feed‐forward loop of renal parenchymal hypoxia and ET synthesis.

Source: Acta Physiologica - February 12, 2018 Category: Physiology Authors: S. N. Heyman, Z. Abassi, C. Rosenberger, H. Yaseen, G. Skarjinski, A. Shina, S. Mathia, N. Krits, M. Khamaisi Tags: ORIGINAL ARTICLE Source Type: research