Enolase ‐1 expression in the stratum corneum is elevated with parakeratosis of atopic dermatitis and disrupts the cellular tight junction barrier in keratinocytes
ConclusionWe found a substantial correlation between ENO1 expression and the rate of nucleated corneocytes in AD and decreased ENO1 expression with nuclear disappearance. These results suggest that high ENO1 expression in the SC of AD is caused by deficient keratinization, which is an AD characteristic. Moreover, ENO1 overexpression in keratinocytes promoted dysfunction of TJ dynamics, leading to reduced integrity of the cellular barrier, and these effects might be mediated by plasmin activity. We propose that ENO1 is a useful indicator of parakeratosis and might have a potential role in cellular TJ barrier function in the epidermis.This article is protected by copyright. All rights reserved.
Source: International Journal of Cosmetic Science - Category: Dermatology Authors: Takeshi Tohgasaki, Naoko Ozawa, Takashi Yoshino, Shioji Ishiwatari, Shoko Matsukuma, Shigeru Yanagi, Hidetsugu Fukuda Tags: Original Article Source Type: research