Neutrophils in systemic onset Juvenile Idiopathic Arthritis display sepsis ‐like features which can be reverted by IL‐1 blockade

ConclusionsOur data argue strongly for an important role for neutrophils in sJIA, especially in the early inflammatory phase, and show susceptibility of neutrophil numbers and inflammatory activity to IL‐1 blockade.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - February 1, 2018 Category: Rheumatology Authors: Nienke M ter Haar, Tamar Tak, Michal Mokry, Rianne C Scholman, Jenny M Meerding, Wilco de Jager, Anouk Verwoerd, Dirk Foell, Thomas Vogl, Johannes Roth, Pieter H C Leliefeld, Jorg van Loosdregt, Leo Koenderman, Sebastiaan J Vastert, Sytze de Roock Tags: Full Length Source Type: research