Neurotransmitter Diversity In Pre ‐Synaptic Terminals Located in the Parvicellular Neuroendocrine Paraventricular Nucleus of the Rat and Mouse Hypothalamus

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The activity of neuroendocrine neurons in the paraventricular nucleus of the hypothalamus (PVH) is controlled by sets of pre‐motor inputs. Using immunohistochemistry and confocal image analysis we examine single and co‐occurrence of catecholaminergic, glutamatergic, and GABAergic markers in synaptophysin‐defined axon terminals in the PVH region that mostly contains CRH neurons. We provide a structural basis for how these transmitter interactions enable adrenocortical responses to fast‐onset interosensory stimuli, and more broadly, how combinations of PVH neurotransmitters and neuromodulators interact dynamically to control adrenocortical activity.

Source: The Journal of Comparative Neurology - February 9, 2018 Category: Neurology Authors: Caroline S. Johnson, Jaideep S. Bains, Alan G. Watts Tags: Research Article Source Type: research