Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary DiseaseNovelty and Significance [Chronic Obstructive Pulmonary Disease]

Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is needed to improve clinical outcomes. We hypothesized that such patients have increased arterial stiffness, wave reflections, and subclinical atherosclerosis compared with controls and that these findings would be independent of smoking status and other confounding factors. A total of 458 patients with a diagnosis of chronic obstructive pulmonary disease and 1657 controls (43% were current or ex-smokers) with no airflow limitation were matched for age, sex, and body mass index. All individuals underwent assessments of carotid–femoral (aortic) pulse wave velocity, augmentation index, and carotid intima–media thickness. The mean age of the cohort was 67±8 years and 58% were men. Patients with chronic obstructive pulmonary disease had increased aortic pulse wave velocity (9.95±2.54 versus 9.27±2.41 m/s; P

Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Marie Fisk, Carmel M. McEniery, Nichola Gale, Kaisa Maki–Petaȷa, Julia R. Forman, Margaret Munnery, Jean Woodcock–Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal–Singer, Michael I. Polkey, John R. Cockcroft, Ian B. Wi Tags: Clinical Studies, Hemodynamics, Aging, Cardiovascular Disease, Risk Factors Original Articles Source Type: research