Dysregulated Expression of RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) Impairs STAT3 (Signal Transducer and Activator of Transcription 3) Signaling to Suppress Trophoblast Cell Migration and Invasion in PreeclampsiaNovelty and Significance [Preeclampsia]

In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnant women. In vitro, inhibition of RPS4Y1 induced trophoblast cell invasion, promoted placental explant outgrowth, and increased STAT3 (signal transducer and activator of transcription 3) phosphorylation along with elevated expression of N-cadherin and vimentin. Conversely, overexpression of RPS4Y1 results in reduced trophoblast cell invasion and decreased STAT3 phosphorylation. In addition, the suppression of RPS4Y1 promotes trophoblast cell invasion, which could be abolished by the STAT3 knockdown. Meanwhile, we observed reductions of STAT3 phosphorylation expression in preeclampsia patients. Collectively, these results demonstrate that the level of RPS4Y1 expression may be associated with preeclampsia by affecting trophoblast cell migration and invasion via the STAT3/epithelial–mesenchymal transition pathway.

Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Xuehai Chen, Chao Tong, Haiying Li, Wei Peng, Rong Li, Xin Luo, Huisheng Ge, Yuxin Ran, Qin Li, Yamin Liu, Xi Xiong, Yuxiang Bai, Hua Zhang, Philip N. Baker, Xiru Liu, Hongbo Qi Tags: High Blood Pressure, Hypertension, Preeclampsia Original Articles Source Type: research