Genetic and Environmental Effects on Gene Expression Signatures of Blood PressureNovelty and Significance [Genetics]

In this study of 391 twins (193 twin pairs and 5 singletons; age 55–69 years; 40% male; 57% monozygous) recruited from the Finnish Twin Cohort, transcriptome-wide data on peripheral leukocytes were obtained using the Illumina HT12 V4 array. Our transcriptome-wide analysis identified 1 gene (MOK [MAPK/MAK/MRK overlapping kinase], P=7.16×10−8) with its expression levels associated with systolic BP at the cutoff of false-discovery rate

Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Yisong Huang, Miina Ollikainen, Pyry Sipila, Linda Mustelin, Xin Wang, Shaoyong Su, Tianxiao Huan, Daniel Levy, James Wilson, Harold Snieder, Jaakko Kaprio, Xiaoling Wang Tags: Genetics Original Articles Source Type: research