Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein CholesterolNovelty and Significance [Epidemiology/Population]

This study aims to characterize the association of statins and LDL-c with central and brachial blood pressures and to quantify their respective effects. Of the 20 004 CARTaGENE participants, 16 507 had available central blood pressure, LDL-c, and Framingham risk score. Multivariate analyses were used to evaluate the association between central pressure and LDL-c in subjects with or without statins. The impact of LDL-c on the association between statin and pressure parameters was determined through mediation analyses. LDL-c was positively associated with systolic and diastolic central pressure in nonusers (β=0.077 and 0.106; P

Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Florence Lamarche, Mohsen Agharazii, Annie–Claire Nadeau–Fredette, Francois Madore, Remi Goupil Tags: Lipids and Cholesterol Original Articles Source Type: research