Transcriptional Profiles of the Pulmonary Innate Immune Response to Isogenic Antibiotic ‐Susceptible and Multidrug‐Resistant Pseudomonas aeruginosa

Abstract The virulence of an isogenic pair of Pseudomonas aeruginosa strains was studied under similar experimental conditions in two animal infection models. Compared to the wild‐type strain, the time to mortality was significantly delayed with the multidrug resistant strain.We further compared the transcriptional profiles of 84 innate immune response genes in the lungs of immunocompetent Balb/C mice. Significantly lower expression levels of genes involved in production of soluble pattern recognition receptor and complement were observed in animals infected with the multidrug resistant strain. Altered patterns of innate immune system activation might explain the attenuated virulence in multidrug resistant bacteria.
Source: Microbiology and Immunology - Category: Microbiology Authors: Tags: Note Source Type: research