Genetic variants in sex hormone pathways and the risk of type 2 diabetes among African ‐American, Hispanic‐American, and European‐American postmenopausal women in the United States

ConclusionWe identified significant signals implicating the PGR gene to T2D development in Hispanic‐American women in the WHI, which are also consistent with GWAS findings linking the PGR gene to glucose homeostasis. Nevertheless, the PGR SNPs‐T2D association was not statistically significant in other ethnic populations. Further studies, especially sex‐specific analyses, are needed to confirm our findings and clarify the role of SHPs in T2D.

Source: Journal of Diabetes - February 8, 2018 Category: Endocrinology Authors: Atsushi Goto, Brian H. Chen, Kei ‐hang K. Chan, Cathy Lee, Sarah C. Nelson, Andrew Crenshaw, Ebony Bookman, Karen L. Margolis, Michèle M. Sale, , Maggie C. Y. Ng, Alexander P. Reiner, Simin Liu Tags: Original Article Source Type: research