Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat

Conclusion: This study also indicates that in vitro hepatic metabolism is over-predictive of ocular metabolism following topically ocular dosed timolol. The research, herein, highlights the eye as an organ capable of first pass metabolism for topical drugs. Thus, new ophthalmologic considerations for studying and designing long term topical therapies in preclinical species are needed in drug discovery.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research