Epigenetic modulation of macrophage polarization- perspectives in diabetic wounds

Diabetes is a chronic metabolic disorder that poses a global burden to healthcare. Increasing incidence of diabetes-related complications in the affected population often includes a delay in wound healing that results in non-traumatic limb amputations. Owing to the intricacies of the healing process and crosstalk between the multitude of participating cells, the identification of hyperglycemia-induced changes at both cellular and molecular level poses a challenge. Macrophages are one of the key participants in wound healing and continue to exert functional changes at the wound site from the time of injury.

Source: Journal of Diabetes and Its Complications - February 7, 2018 Category: Endocrinology Authors: Sanchari Basu Mallik, B.S. Jayashree, Rekha R. Shenoy Tags: Review article Source Type: research