Region ‐specific ischemia, neovascularization and macular edema in treatment‐naïve proliferative diabetic retinopathy

Conclusions and RelevanceThe region‐specific correlation of non‐perfusion‐index of far‐periphery and neovascularization‐index of mid‐periphery, but not with central retinal thickness, suggests different pathogeneses of neovascularization and macular edema. Retinal nerve fiber layer and ganglion cell layer, both biomarkers of diabetic retinal neuronopathy, are associated with retinal ischemia, but not with macular edema, suggesting that diabetic microangiopathy and neuronopathy possess distinct pathogenic pathways. The strong correlation between macular edema and inner nuclear layer indicates that intracellular edema is a determining factor of diabetic macular edema.
Source: Clinical and Experimental Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research