Sexually Transmitted Infections and Immune Activation among HIV-Infected but Virally Suppressed Youth on Antiretroviral Therapy

Human immunodeficiency virus (HIV) infection is associated with chronic immune activation leading to loss of T-cells and HIV disease progression [1]. HIV replication in lymph nodes alters node structure, further decreasing CD4+ T-cells [2 –4]. Markers of immune activation are associated with declining CD4+ T-cell counts [5], HIV disease progression, [6] and development of persistent inflammation that is not fully reversed by combination antiretroviral therapy (cART) [7–9].

Source: Journal of Clinical Virology - February 6, 2018 Category: Virology Authors: Tanya L. Kowalczyk Mullins, Su X. Li, James Bethel, Maureen M. Goodenow, Stephanie Hudey, John W. Sleasman, the Adolescent Medicine Trials Network for HIV AIDS Interventions Tags: Short communication Source Type: research